The Center for Neuroproteomics and Biomarkers Research was established in 2004 in response to the scientific and clinical demands for discovery of human and rodent proteomes in the nervous system for identification of distinct proteins with changes in expression levels that correlate with the onset or progression of a specific neural disease. Biomarker research in medicine will improve diagnosis, strengthen short- and long-term patient care, and assist clinical trials for new therapy development. The development of research or diagnostic biomarkers focusing on non-invasive detection of blood and/or cerebrospinal fluid proteins, peptide fragments and biochemical molecules that are associated with the magnitude of various CNS disorders and are reliable predictors of severity of disorder and/or efficacy of drug intervention. This research center of excellence takes full advantage of the significant instrumentation and infrastructure and human resources investment from the McKnight Brain Institute in order to form a multidisciplinary approach of biomedical engineering, bioinformatics, basic science, and clinical science. We are building a rich and rapidly expanding portfolio of nervous system disease projects encompassing various neurological, psychiatric and neurodegenerative disorders. It is our mission to become the nation’s best Research Center of Excellence in neuroproteomics and neuro-biomarker research, while expanding research opportunities through aggressive public, industrial and private funding. We also are collaborating with researchers within the McKnight Brain Institute and other UF departments in order to explore commercialization opportunities for any neuro-proteomic and neuro-diagnostic technologies and products developed at the CNBR.